Complement in Hemolytic Disease of the Newborn

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Complement in hemolytic disease of the newborn.

demomnstrated loiv conncenntrat.ionns of complement shortly after the occurrennce of hemobytic crises inn paroxysmal cold hemogbobinnuria. Young, et al.4 foumnd that the complement bevels of dogs dropped sharply aind rose fain-ly promptly to normal values after the production of intravascular hemobysis by the adminnistrationn of imncompatible blood transfusions. Dacie amid de Gruchy5 reported a...

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Hemolytic Disease of the Newborn

Hemolytic disease of the newborn (HDN), with high potential for increased fetal loss is less common now, due to the universal screening for iso-sensitization and also because of appropriate use of antenatal anti-RhD antibody prophylaxis. There are other non-RhD antibodies that can cause HDN. In US, we occasionally encounter a highly sensitized fetus with significant morbidity and mortality. In ...

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Blueberry Muffin Rash in a Patient with Hemolytic Disease of the Newborn Due to Anti-Cw

Blueberry muffin rash is a characteristic multiple bluish skin nodules associated with perinatal infection, severe and chronic anemia, and neoplastic infiltrative diseases. We present an unusually severe case of hemolytic disease of the newborn. He required exchange transfusions for several times. The complete work up led to the diagnosis of anti-Cw. The skin lesion regressed spontaneously with...

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The Use of Complement in the Serological Diagnosis of Hemolytic Disease of the Newborn

Dacie1, in 1950, called attention to the part played by fresh serum in red cell absorption of cold auto-antibodies. He noted that sensitization did not occur when heat inactivated serum was used and that absorption was inhibited by heparin, oxalate and citrate. The similarity of this property of fresh serum to complement is obvious and recent efforts by many workers have left little doubt that ...

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Erythrophagocytosis in hemolytic disease of the newborn.

By MARY B. COOPER, B.A., M.T. (ASCP) I N 1909, Buchan and Comrie” reported the occurrence of erythrophagocytes in the peripheral blood of 2. newborn infants with ‘ ‘congenital anemia and enlargement of the spleen. ‘ ‘ In 193 I , Abt2 described these cells in blood smears of a case of anemia of the newborn. In 1938, Wyatt, Cooper and Groat9 reported 3 cases of the same disease in which the cells...

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ژورنال

عنوان ژورنال: Blood

سال: 1954

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v9.5.505.505